Evaluation of Red Blood Cells Parameters among Chronic Kidney Disease Patients in Shendi Town, Sudan

Abstract

Abstract:
Background: Chronic kidney disease is a worldwide public health problem. It is associated with
various hematological abnormalities that lead to morbidity and mortality, as well as being the main
cause of anemia. Objectives: This study aimed to evaluate the hematological parameters (hemoglobin
concentration, RBC count, HCT percent, RBC indices, and RBC distribution width) in chronic kidney
disease patients. Also to describe the effect of disease duration on haemoglobin concentration and red
blood cell count. Methods: This is a case-control analytical study on 50 chronic kidney disease patients
at Almak Neimer Hospital, Shendi City, Sudan. Hematological parameters, especially red blood cell
parameters, were measured using standard techniques by using a CBC automated hematological
analyzer (Mindary BC 3000) in chronic kidney disease cases, and the findings were compared with
age- and sex-matched healthy group controls. Results were analyzed using SPSS 26 for Windows.
Results: The mean of hemoglobin concentration, hematocrit percent, red blood cell count, RBC
indices, and RBC distribution width. Were reduced and statistically significant in chronic kidney
disease patients compared to controls (p <0.05). Also, the increased duration of the disease leads to a
significant decrease in mean hemoglobin concentration, RBC count, and hematocrit percent.
Conclusion: Haematological parameters are deranged in patients with chronic kidney disease. Routine
evaluation of these parameters is useful in the management of these patients.
Keywords: Chronic kidney disease, Anemia, Erythropoietin, Hematological parameters.