Correlation of CBC Parameters and Immunophenotyping in Acute Lymphoblastic Leukaemia Patients in Khartoum State, Sudan

Abstract

Abstract:

Background: Acute lymphoblastic leukemia, a malignant disorder of lymphoid progenitor cells, affects both children and adults, with peak prevalence between the ages of 2 and 5 years. Objectives: This study aimed to estimate the complete blood count and immunophenotyping and correlate the parameter results among acute lymphoblastic leukemia Sudanese patients. Methods: An analytical cross-sectional study was conducted in Khartoum Hospital for Oncology and Flow Cytometry Centre from January to April 2023 on a total of one hundred fifty venous blood samples collected from acute lymphoblastic leukemia patients. A complete hemogram was then done using an automated cell counter (Mindray BC 6800) and flow cytometry. Results: For compassion of CBC between B cells and T cells type, WBCS was significantly higher in T cell type compared to B cell type (162.2 ± 25.0 vs 43.3 ± 4.8)p-value 0.000* respectively, RBCS did not significantly differ in T cell type and B cell type (2.7 ± 0.9 vs 2.7 ± 0.8)p-value 0.843, platelet was not significantly differed in T cell type and B cell type (45.4 ± 4.3 vs 51.3 ± 7.2)p-value 0.525 respectively, HB did not significantly differ in T cell type and B cell type (8.7 ± 0.6 vs 8.7 ± 0.6)p-value 0.942 respectively, Blast was not significantly differed in T cell type and B cell type (68.3 ± 19.6 vs 60.9 ± 18.3) p-value 0.052, For correlations of age with CBC, all parameters were not significantly correlated with age. Conclusion: The study concludes that anemia and thrombocytopenia were observed in almost all patients, white blood cells were significantly higher in the T cell type compared to the B cell type.Keywords: Acute Lymphoblastic Leukemia, Correlation, CBC, Immunophenotyping, Laboratory parameters, Sudan