Correlation of CBC Parameters and Immunophenotyping in Acute Lymphoblastic Leukaemia Patients in Khartoum State, Sudan

Authors

  • Mohanad Abdelghafar Abdelaziz Elsheikh1 Author
  • Albaraa Abdulfatah Mohammed1 Author
  • Ghanem Mohammed Mahjaf2 Author
  • Tibyan Abd Almajed Altaher3, Mayada Mansoor Seliman Abdalla4 Author
  • Mosab Nouraldein Mohammed Hamad5 Author

DOI:

https://doi.org/10.58971/twnk5m79

Abstract

Abstract:

Background: Acute lymphoblastic leukemia, a malignant disorder of lymphoid progenitor cells, affects both children and adults, with peak prevalence between the ages of 2 and 5 years. ObjectivesThis study aimed to estimate the complete blood count and immunophenotyping and correlate the parameter results among acute lymphoblastic leukemia Sudanese patients. Methods: An analytical cross-sectional study was conducted in Khartoum Hospital for Oncology and Flow Cytometry Centre from January to April 2023 on a total of one hundred fifty venous blood samples collected from acute lymphoblastic leukemia patients. A complete hemogram was then done using an automated cell counter (Mindray BC 6800) and flow cytometry. ResultsFor compassion of CBC between B cells and T cells type, WBCS was significantly higher in T cell type compared to B cell type (162.2 ± 25.0 vs 43.3 ± 4.8)p-value 0.000* respectively, RBCS did not significantly differ in T cell type and B cell type (2.7 ± 0.9 vs 2.7 ± 0.8)p-value 0.843, platelet was not significantly differed in T cell type and B cell type (45.4 ± 4.3 vs 51.3 ± 7.2)p-value 0.525 respectively, HB did not significantly differ in T cell type and B cell type (8.7 ± 0.6 vs 8.7 ± 0.6)p-value 0.942 respectively, Blast was not significantly differed in T cell type and B cell type (68.3 ± 19.6 vs 60.9 ± 18.3) p-value 0.052, For correlations of age with CBC, all parameters were not significantly correlated with age. ConclusionThe study concludes that anemia and thrombocytopenia were observed in almost all patients, white blood cells were significantly higher in the T cell type compared to the B cell type.Keywords: Acute Lymphoblastic Leukemia, Correlation, CBC, Immunophenotyping, Laboratory parameters, Sudan

 

Published

2025-04-09

How to Cite

Correlation of CBC Parameters and Immunophenotyping in Acute Lymphoblastic Leukaemia Patients in Khartoum State, Sudan. (2025). Excellence Journal for Medical Sciences, 5(1). https://doi.org/10.58971/twnk5m79